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KMID : 1100220110100010015
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Dementia and Neurocognitive Disorders
2011 Volume.10 No. 1 p.15 ~ p.21
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The Influences of White Matter Hyperintensities on the Specific Cognitive Decline in the Patients with Mild Cognitive Impairment
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Ku Bon-D.
Park Key-Chung
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Abstract
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Background: It is still unclear that white matter hyperintensities (WMH) would affect the specific cognitive decline of the patients with mild cognitive impairment (MCI). We explored whether WMH influence the specific cognitive decline to the patient with MCI.
Methods: Patients with MCI were recruited from August 2005 to February 2009. We evaluated the degree of WMH by the combination of deep and periventricular WMH. Patients with MCI were divided into groups with minimal (Group I), moderate (Group II) and severe (Group III) hyperintensities by the degree of WMH. Being regarded as subcortical vascular MCI, the patients in the Group III were excluded. According to the affected cognitive domain, patients were divided into amnestic single, amnestic multiple, non-amnestic single and non-amnestic multiple MCI.
Results: A total of 156 patients were recruited (118 in Group I and 38 in Group II). Mean score of MMSE was 24.9±3.1 and that of CDR was 0.5±0.1. The most frequent subtype was amnestic multiple MCI (67.9%). There were no differences in the affected cognitive domains and distribution of the MCI subtype between Group I and Group II. However, the frontal cognitive function declined significantly, in proportion to the increasing periventricular WMH.
Conclusions: These results suggest that increasing of periventricular WMH may affect to the frontal cognitive decline in patients with MCI.
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KEYWORD
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White matter hyperintensities, Mild cognitive impairment, Perventricular white matter, Deep white matter, Cognitive domain
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